Brock University
Inhibiting GSK3 to Preserve Musculoskeletal and Cognitive Health during Spaceflight — Canada has committed efforts to push humanity further into the solar system beyond the International Space Station to more distant destinations like the Moon and Mars. However, travelling with the astronauts on these longer-duration missions are risks for muscle loss and weakness, bone fragility and cognitive decline, all of which will compromise astronaut well-being and the mission at hand. This research seeks to determine whether stopping an enzyme called glycogen synthase kinase 3 can slow the functional decline of muscles, bone, and brain not only in space but also here on Earth, providing novel therapeutic strategies for human health.